Back to the 'essence of medical treatment in oncology: the 2015 WHO Model List of Essential Medicines
Introduction
Forty years ago, a group of physicians gathered in Nice, France, with a shared optimism for the promise of systemic therapies to treat cancer. This conference became the inaugural meeting of what is now the European Society for Medical Oncology (ESMO), which today convenes nearly 20,000 individuals from around the world. At that time,...
NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
Find the Fact Sheet on NTRK/TrkB here: http://oncologypro.esmo.org/Publications/Glossary-of-Molecular-Biology/Glossary-in-Molecular-Biology
Introduction
The treatment of solid tumours is dramatically changing in recent years thanks to the enhancement of molecular diagnostic technologies leading to identification of an increasing number of specific actionable oncogenic abnormalities such as gene activating point mutations, in-frame insertions/deletions and amplification or rearrangements. The concept of precision...
Cancer and liver cirrhosis: implications on prognosis and management
Careful evaluation of the aetiology and severity of liver cirrhosis is necessary prior to initiation of anticancer treatment. Modifiable causal factors (eg, alcohol, liver toxins including drugs with known hepatotoxicity, diabetes) should be corrected in order to prevent worsening of the liver disease. Additionally, patients should be screened for portal hypertension and its complications...
